Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8NETP)

Drug Name

ARH-1029 Drug Info

Synonyms

AR-HP; Dual-acting H. pylori therapeutic (peptic ulcer disease), CJ Corp; Dual-acting H. pylori therapeutic, (peptic ulcer disease), Taiho Pharmaceutical

Indication

Disease Entry	ICD 11	Status	REF
Helicobacter infection	DA42-DA63	Investigative	[1]

Cross-matching ID

TTD Drug ID: DM8NETP

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastric H(+)/K(+) ATPase alpha (ATP4A)	TTF1QVM	ATP4A_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Gastric H(+)/K(+) ATPase alpha (ATP4A)	DTT	ATP4A	4.385	5.146	4.062	5.066

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Helicobacter infection

ICD Disease Classification

DA42-DA63

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Gastric H(+)/K(+) ATPase alpha (ATP4A)	DTT	ATP4A	1.42E-02	-0.15	-1.5

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849).