Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8P05S)

Drug Name
PS-388023 Drug Info
Synonyms
PS-680648; PS-780035; Angiogenesis inhibitors (ocular indications), Pharmacopeia/Allergan; Angiogenesis inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin avb3/avb5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia; Dual integrin alpha-5/beta-3 + alpha-5/beta-5 inhibitors (inflammatory/ocular/oncological indications), Pharmacopeia
Indication
Disease Entry ICD 11 Status REF
Ocular disease 1F00.1Z Terminated [1]
Cross-matching ID
TTD Drug ID
DM8P05S

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin alpha-V/beta-3 (ITGAV/B3) TT69TQN ITAV_HUMAN-ITB3_HUMAN Modulator [2]
Integrin alpha-V/beta-5 (ITGAV/B5) TTPRDH7 ITAV_HUMAN-ITB5_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Integrin alpha-V/beta-5 (ITGAV/B5) DTT ITGAV-ITGB5 6.811 6.865 7.208 7.353
Integrin alpha-V/beta-3 (ITGAV/B3) DTT ITGAV-ITGB3 3.916 4.104 5.776 4.121
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Ocular disease
ICD Disease Classification 1F00.1Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Integrin alpha-V/beta-5 (ITGAV/B5) DTT ITGAV-ITGB5 2.88E-04 2.42 1.71
Integrin alpha-V/beta-3 (ITGAV/B3) DTT ITGAV-ITGB3 8.19E-02 -0.16 -0.46
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022665)
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.