Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8WB96)

• Drug Name: 5-Benzyloxy-benzo[b]thiophene-2-carboxamidine Drug Info
• Synonyms: CHEMBL598385; 5-Benzyloxy-benzo[b]thiophene-2-carboxamidine; SCHEMBL13709665

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 46233192
  TTD Drug ID: DM8WB96

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor IX (F9)	TTFEZ5Q	FA9_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Coagulation factor IX (F9)	DTT	F9	11.652	4.365	4.591	4.667

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor IX (F9)	DTT	F9	5.69E-01	-0.13	-0.45

References

• [1] Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72.