Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM904B6)

• Drug Name: Lorglumide Drug Info
• Synonyms: Lorglumide; 97964-56-2; Lorglumide [INN]; Lorglumidum [Latin]; Lorglumida [Spanish]; CR-1409; CCRIS 6857; CHEMBL24938; CHEBI:88307; CR 1409; D,L-4-(3,4-Dichlorobenzoylamino)-5-(dipentylamino)-5-oxo-pentanoic acid; Lorglumida; Lorglumidum; (+-)-4-(3,4-Dichlorobenzamido)-N,N-dipentylglutaramic acid; 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid; Pentanoic acid, 4-((3,4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxo-, (+-)-; C22H32Cl2N2O4; 4-((3,4-dichlorobenzoyl)amino)-5-(dipentylamino)-5-oxopentanoic a

Indication

Disease Entry	ICD 11	Status	REF
Pancreatic malfunction	DC30-DC3Z	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 3960
  ChEBI ID: CHEBI:88307
  CAS Number: CAS 97964-56-2
  TTD Drug ID: DM904B6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholecystokinin receptor type A (CCKAR)	TTCG0AL	CCKAR_HUMAN	Antagonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cholecystokinin receptor type A (CCKAR)	DTT	CCKAR	3.907	4.133	2.858	3.892

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Pancreatic malfunction
• ICD Disease Classification: DC30-DC3Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cholecystokinin receptor type A (CCKAR)	DTT	CCKAR	9.99E-01	-0.03	-0.2

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 891).
• [2] Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety. Hokkaido Igaku Zasshi. 1998 Sep;73(5):463-73.