Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM906JK)

• Drug Name: Pyrrolidine-1-carbonitrile Drug Info
• Synonyms: Pyrrolidine-1-carbonitrile; 1530-88-7; 1-Pyrrolidinecarbonitrile; 1-Cyanopyrrolidine; N-Cyanopyrrolidine; CHEMBL262697; QJRYYOWARFCJQZ-UHFFFAOYSA-N; pyrrolidinecarbonitrile; cyanopyrrolidine; Cyano-Pyrrolidine; NSC44225; EINECS 216-234-3; Tetramethylenecyanamide; AC1L2KEM; AC1Q4SLA; 1-pyrrolidine carbonitrile; CTK0I1775; DTXSID90165192; MolPort-000-145-877; ZINC1676633; KS-00002AX2; NSC-44225; 4756AD; BDBM50095495; SBB059310; AKOS006227753; MCULE-2010942719; PS-9344; CJ-27397; AN-49391; KB-65041; FT-0607667; ST51044369; P2337; A827637

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 73737
  CAS Number: CAS 1530-88-7
  TTD Drug ID: DM906JK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin K (CTSK)	TTDZN01	CATK_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cathepsin K (CTSK)	DTT	CTSK	7.502	8.157	6.955	8.046

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cathepsin K (CTSK)	DTT	CTSK	2.85E-01	-1.14	-2.61

References

• [1] Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43.