General Information of Drug (ID: DM93XJT)

Drug Name
2-(phenylsulfonyl)-1-p-tolylethanone Drug Info
Synonyms
38488-14-1; CHEMBL392808; Ethanone, 1-(4-methylphenyl)-2-(phenylsulfonyl)-; 2-(phenylsulfonyl)-1-p-tolylethanone; 4-Methylphenacylphenyl sulfone; SCHEMBL6202982; CTK1A8876; DTXSID20575987; BDBM50212530; ZINC28874639; AKOS008967833; 1-p-Tolyl-2-(phenylsulphonyl)ethanone; 1-(4-methylphenyl)-2-(phenylsulfonyl)ethanone; 2-(Benzenesulfonyl)-1-(4-methylphenyl)ethan-1-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15627039
CAS Number
CAS 38488-14-1
TTD Drug ID
DM93XJT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 10.967 5.178 5.865 6.377
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 2.03E-01 -0.01 -0.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405.