Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM94B7N)

Drug Name
2-(3-(phenylsulfonyl)-1H-indol-1-yl)ethanamine Drug Info
Synonyms CHEMBL188182; 2-(3-(phenylsulfonyl)-1H-indol-1-yl)ethanamine; SCHEMBL5787166; BDBM50155140
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10017687
TTD Drug ID
DM94B7N

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 6 receptor (HTR6) TTJS8PY 5HT6R_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 6 receptor (HTR6) DTT HTR6 5.594 5.781 5.271 3.963
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 6 receptor (HTR6) DTT HTR6 1.23E-05 -0.12 -0.71
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63.