General Information of Drug (ID: DM94V8D)

Drug Name
5,6-dihydroxy-7-nitro-2,3-dihydroinden-1-one Drug Info
Synonyms 5,6-dihydroxy-7-nitro-1-indanone; 383382-47-6; CHEMBL9039; SCHEMBL7432202; ULOQNEJBWLIGHK-UHFFFAOYSA-N; 5,6-Dihydroxy-7-nitro-indan-1-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9920742
TTD Drug ID
DM94V8D

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Catechol-O-methyl-transferase (COMT) TTKWFB8 COMT_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Catechol-O-methyl-transferase (COMT) DTT COMT 8.791 7.048 7.478 7.165
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Catechol-O-methyl-transferase (COMT) DTT COMT 9.24E-02 0.17 1.09
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. J Med Chem. 2005 Dec 15;48(25):8070-8.