Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9FHV8)

Drug Name

CK-2127107 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Phase 2	[1]
Spinal muscular atrophy	8B61	Phase 2	[1]
Muscle atrophy	FB32.Y	Phase 1	[2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fast skeletal muscle troponin complex (TNNC2)	TTYUMF5	TNNC2_HUMAN	Modulator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Fast skeletal muscle troponin complex (TNNC2)	DTT	TNNC2	2.263	5.989	4.755	6.029

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Amyotrophic lateral sclerosis

ICD Disease Classification

8B60.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fast skeletal muscle troponin complex (TNNC2)	DTT	TNNC2	3.79E-01	0.02	0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037810)
3	Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5.