Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9JLUS)

Drug Name

6,7-dihydroxy-8-nitro-1-tetralone Drug Info

Synonyms

383382-48-7; 1(2h)-naphthalenone,3,4-dihydro-6,7-dihydroxy-8-nitro-; CHEMBL8752; SCHEMBL7428171; CTK8I5216; 1(2H)-Naphthalenone, 3,4-dihydro-6,7-dihydroxy-8-nitro-; ZINC25989269

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9877868
TTD Drug ID: DM9JLUS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Catechol-O-methyl-transferase (COMT)	TTKWFB8	COMT_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Catechol-O-methyl-transferase (COMT)	DTT	COMT	8.791	7.048	7.478	7.165

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Catechol-O-methyl-transferase (COMT)	DTT	COMT	9.24E-02	0.17	1.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. J Med Chem. 2005 Dec 15;48(25):8070-8.