Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9P62Y)

Drug Name

GKA1 Drug Info

Synonyms

CHEMBL381434; GKA1; SCHEMBL1794696; RTMFZNZPHCZAFG-UHFFFAOYSA-N; ZINC28523790; BDBM50165037; 6-(3-Isobutoxy-5-isopropoxy-benzoylamino)-nicotinic acid; 6-[(3-isobutoxy-5-isopropoxybenzoyl)amino]-3-pyridinecarboxylic acid; 6-[(3-isobutoxy-5-isopropoxvbenzoyl)amino]-3-pyridinecarboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10044792
TTD Drug ID: DM9P62Y

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucokinase (GCK)	TTDLNGZ	HXK4_HUMAN	Activator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucokinase (GCK)	DTT	GCK	2.722	4.76	1.848	3.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucokinase (GCK)	DTT	GCK	2.72E-01	0.76	0.52

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators. Diabetes. 2004 Mar;53(3):535-41.