Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9UMIO)

Drug Name
JNJ-38518168 Drug Info
Indication
Disease Entry ICD 11 Status REF
Plaque psoriasis EA90.0 Phase 2 [1]
Rheumatoid arthritis FA20 Phase 2 [2]
Cross-matching ID
PubChem CID
23650961
CAS Number
CAS 952494-46-1
TTD Drug ID
DM9UMIO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H4 receptor (H4R) TTXJ178 HRH4_HUMAN Antagonist [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Histamine H4 receptor (H4R) DTT HRH4 5.238 4.933 4.347 4.022
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Plaque psoriasis
ICD Disease Classification EA90.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Histamine H4 receptor (H4R) DTT HRH4 3.67E-01 -0.05 -0.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 ClinicalTrials.gov (NCT02295865) A Study to Evaluate Safety and Efficacy of Toreforant (JNJ-38518168) in Participants With Moderate to Severe Plaque-type Psoriasis. U.S. National Institutes of Health.
3 The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015; 6: 65.