Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9VQ0T)

Drug Name
4-Hydroxy-piperidine-3-carboxylic acid Drug Info
Synonyms CHEMBL277372; SCHEMBL5426302; ZINC26898692; BDBM50223874; AKOS006353852; (3S)-4alpha-Hydroxypiperidine-3alpha-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
21125089
TTD Drug ID
DM9VQ0T

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA transporter GAT-1 (SLC6A1) TTPRKM0 SC6A1_HUMAN Inhibitor [1]
GABA transporter-3 (SLC6A11) TT8RXO5 S6A11_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
GABA transporter GAT-1 (SLC6A1) DTT SLC6A1 8.477 4.548 4.194 5.53
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
GABA transporter GAT-1 (SLC6A1) DTT SLC6A1 4.99E-02 -0.24 -0.62
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62.