Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9YCAH)

Drug Name

2-Aminothiazoline Drug Info

Synonyms

2-Amino-2-thiazoline; 1779-81-3; 4,5-dihydrothiazol-2-amine; 2-Iminothiazolidine; 2-Thiazolidinimine; 2-Thiazolamine, 4,5-dihydro-; 2-Amino-4,5-dihydrothiazole; 2-Thiazoline, 2-amino-; 4,5-Dihydro-1,3-thiazol-2-amine; USAF PD-57; 2-Amino-4,5-dihydrothiazoline; 4,5-DIHYDRO-2-THIAZOLAMINE; 2-Thiazolin-2-ylamine; 2-Aminothiazoline (VAN); UNII-5JC2YZG56Q; NSC 3110; NSC 24626; Thiazolidin-(2E)-ylideneamine; 2-Amino-DELTA2-thiazoline; EINECS 217-224-1; 5JC2YZG56Q; CHEMBL362148; 2-Amino-2-thiazoline, 97%

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15689
ChEBI ID: CHEBI:40889
CAS Number: CAS 1779-81-3
TTD Drug ID: DM9YCAH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nitric-oxide synthase brain (NOS1)	TTZUFI5	NOS1_HUMAN	Inhibitor	[2]
Nitric-oxide synthase endothelial (NOS3)	TTCM4B3	NOS3_HUMAN	Inhibitor	[1]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nitric-oxide synthase brain (NOS1)	DTT	NOS1	6.085	5.844	5.849	5.806
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.95	5.198	4.573	5.121
Nitric-oxide synthase endothelial (NOS3)	DTT	NOS3	4.787	4.154	5.133	3.053

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nitric-oxide synthase inducible (NOS2)	DTT	NOS2	4.24E-02	-0.27	-0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44.