Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAEN9Y)

Drug Name

Adamantan-1-yl-pyrrolidin-1-yl-methanone Drug Info

Synonyms

Adamantan-1-yl-pyrrolidin-1-yl-methanone; CHEMBL392866; 1-adamantyl(1-pyrrolidinyl)methanone; 22508-51-6; (3r,5r,7r)-adamantan-1-yl(pyrrolidin-1-yl)methanone; 1-adamantyl(pyrrolidin-1-yl)methanone; AC1MCDV9; CBMicro_007397; Cambridge id 5142982; Oprea1_111627; Oprea1_295021; MLS000526196; adamantanyl pyrrolidinyl ketone; SCHEMBL3456185; MolPort-001-930-821; HMS2477C05; HMS1608M03; ZINC4031845; SMSF0003738; STK091400; BDBM50207788; 1-(adamantane-1-carbonyl)pyrrolidine; AKOS000612243; CCG-246226; CB09819; MCULE-7009966643

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2741656
CAS Number: CAS 22508-51-6
TTD Drug ID: DMAEN9Y

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	TTN7BL9	DHI1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	10.967	5.178	5.865	6.377

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DTT	HSD11B1	2.03E-01	-0.01	-0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43.