Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAFQE1)

Drug Name

UVAOL Drug Info

Synonyms

Uvaol; 545-46-0; Urs-12-ene-3beta,28-diol; Urs-12-ene-3,28-diol; UNII-W599R31ROT; W599R31ROT; CHEMBL399873; CHEBI:67894; (3beta)-Urs-12-ene-3,28-diol; (3S,4aR,6aR,6bS,8aS,11R,12S,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol; EINECS 208-888-3; NSC 159627; Uvaol, > AC1L3OV7; SCHEMBL337913; BCBcMAP01_000233; MolPort-003-959-866; 3-beta,28-Dihydroxy-urs-12-ene; ZINC3978797

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 92802
ChEBI ID: CHEBI:67894
CAS Number: CAS 545-46-0
TTD Drug ID: DMAFQE1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PTPN1 messenger RNA (PTPN1 mRNA)	TTELIN2	PTN1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
PTPN1 messenger RNA (PTPN1 mRNA)	DTT	PTPN1	3.667	2.293	2.609	4.573

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
PTPN1 messenger RNA (PTPN1 mRNA)	DTT	PTPN1	9.44E-01	7.21E-03	0.08

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8.