Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAMFXC)

Drug Name
BCG65-E7 Drug Info
Indication
Disease Entry ICD 11 Status REF
Anal intraepithelial neoplasia 2E92.5 Discontinued in Phase 3 [1]
Human papillomavirus infection 1A9Y Discontinued in Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMAMFXC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 3 (TLR3) TTD24Y0 TLR3_HUMAN Agonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Toll-like receptor 3 (TLR3) DTT TLR3 4.256 5.833 5.916 6.583
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anal intraepithelial neoplasia
ICD Disease Classification 2E92.5
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Toll-like receptor 3 (TLR3) DTT TLR3 4.85E-01 0.63 0.83
Toll-like receptor 3 (TLR3) DTT TLR3 8.00E-01 0.11 0.1
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009576)
2 Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12.