Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMANU3W)

• Drug Name: AS-602704 Drug Info
• Synonyms: 339990-02-2; AIPs (Alzheimers), Axonyx/Serono; Ac-LPFFD-NH2; amyloid-inhibiting peptides, Serono/Axonyx; beta-amyloid inhibitors, Serono/Axonyx; beta-sheet breaker peptides (Alzheimers), Serono/Axonyx

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DMANU3W

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amyloid beta A4 protein (APP)	TTE4KHA	A4_HUMAN	Modulator	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Amyloid beta A4 protein (APP)	DTT	APP	6.473	8.014	8.631	7.57

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Amyloid beta A4 protein (APP)	DTT	APP	1.60E-02	-0.07	-0.31

References

• [1] Transport characteristics of a beta sheet breaker peptide across excised bovine nasal mucosa. Drug Dev Ind Pharm. 2007 Jan;33(1):71-7.