Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAPRWV)

Drug Name

SaxaDapa FDC Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 3	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dipeptidyl peptidase 4 (DPP-4)	TTDIGC1	DPP4_HUMAN	Modulator	[1]
Sodium/glucose cotransporter 2 (SLC5A4)	TTN7Y4P	SC5A4_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Sodium/glucose cotransporter 2 (SLC5A4)	DTT	SLC5A4	4.858	4.892	6.485	3.838
Dipeptidyl peptidase 4 (DPP-4)	DTT	DPP4	4.995	4.926	7.852	8.358

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Sodium/glucose cotransporter 2 (SLC5A4)	DTT	SLC5A4	3.26E-01	-0.09	-0.37
Dipeptidyl peptidase 4 (DPP-4)	DTT	DPP4	9.54E-01	-0.27	-1.85

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes. Cardiol Rev. 2010 Jul-Aug;18(4):213-7.