General Information of Drug (ID: DMAROTU)

Drug Name
RPKPfQwFwLL-NH2 Drug Info
Synonyms
96736-12-8; Antagonist D; [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-substance P; CHEMBL501261; D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P; rPKPfQwFwLL-NH2; MFCD00076802; BDBM50260268; AKOS024456872; CA-1583; [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P, > (D-Arg1,D-Phe5,D-Trp7 inverted exclamation mark currency9,Leu11)-Substance P
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25091011
TTD Drug ID
DMAROTU

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Growth hormone secretagogue receptor 1 (GHSR) TTWDC17 GHSR_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Growth hormone secretagogue receptor 1 (GHSR) DTT GHSR 2.609 4.104 4.797 1.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Growth hormone secretagogue receptor 1 (GHSR) DTT GHSR 4.56E-01 -0.14 -0.74
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811.