Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAZ1NW)

Drug Name

FXI-AS1 Drug Info

Synonyms

FXI antisense oligonucleotides (thrombosis); FXI-AS2; FXI-ASO; ISIS-404071; FXI antisense oligonucleotides (thrombosis), Isis Pharmaceuticals; Factor XI antisense oligonucleotides (thrombosis), Isis Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMAZ1NW

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Factor XI messenger RNA (F11 mRNA)	TTDM4ZU	FA11_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Factor XI messenger RNA (F11 mRNA)	DTT	F11	8.057	5.368	5.527	5.485

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Thrombosis

ICD Disease Classification

DB61-GB90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Factor XI messenger RNA (F11 mRNA)	DTT	F11	8.24E-01	-3.39E-03	-0.04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2360).