Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBLUSA)

Drug Name

MF-152 Drug Info

Synonyms

916888-66-9; 2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide; CHEMBL576820; MF-152; SCHEMBL3467167; KS-00000RND; DTXSID60474965; MolPort-035-675-701; ZINC45288748; BDBM50301057; AKOS022171752; 2-[4-[2-(trifluoromethyl)benzoyl]piperazin-1-yl]-1,3-thiazole-5-carboxamide; DS-5323; ACN-025269; BC261397; AK136241; SC-94064; KB-222046; AJ-110396

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11973722
CAS Number: CAS 916888-66-9
TTD Drug ID: DMBLUSA

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acyl-CoA desaturase (SCD)	TT6RIOV	ACOD_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Acyl-CoA desaturase (SCD)	DTT	SCD	7.165	5.49	3.271	6.434

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Acyl-CoA desaturase (SCD)	DTT	SCD	4.73E-01	0.2	0.54

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7.