Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBMOI6)

Drug Name
WF-2421 Drug Info
Synonyms FR-900280
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Terminated [1]
Cross-matching ID
PubChem CID
195567
CAS Number
CAS 128429-19-6
TTD Drug ID
DMBMOI6

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aldose reductase (AKR1B1) TTFBNVI ALDR_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aldose reductase (AKR1B1) DTT AKR1B1 7.436 8.652 9.874 8.066
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Diabetic complication
ICD Disease Classification 5A2Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aldose reductase (AKR1B1) DTT AKR1B1 1.08E-20 0.94 1.58
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991 Feb;44(2):130-5.