Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBT2RJ)

Drug Name

MC-2001 Drug Info

Synonyms

MC-2002; MC-2006; Multiple selective kinase inhibitors (leukemia); Dual Flt3/ABL inhibitors, MaxoCore; Multiple selective kinase inhibitors (leukemia), Maxocore

Indication

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Preclinical	[1]

Cross-matching ID

TTD Drug ID: DMBT2RJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fms-like tyrosine kinase 3 (FLT-3)	TTGJCWZ	FLT3_HUMAN	Inhibitor	[2]
Tyrosine-protein kinase ABL1 (ABL)	TT3PJMV	ABL1_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

leukaemia

ICD Disease Classification

2A60-2B33

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fms-like tyrosine kinase 3 (FLT-3)	DTT	FLT3	2.11E-01	-0.05	-0.16

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021088)
2	Vascular endothelial growth factor and its receptors in multiple myeloma. Leukemia. 2003 Oct;17(10):1961-6.