General Information of Drug (ID: DMC0FLB)

Drug Name
BAS-01047655 Drug Info
Synonyms
BAS-01047655; CHEMBL380706; AC1LKNKS; MolPort-001-663-455; MolPort-019-782-693; ZINC12376560; STK392633; BDBM50187570; AKOS000548089; MCULE-2522435117; ST033733; BAS 01047655; AK-968/37005047; A2180/0091610; 4-[2-(benzyloxy)benzylidene]-1-phenyl-3,5-pyrazolidinedione; 4-(2-Benzyloxy-benzylidene)-1-phenyl-pyrazolidine-3,5-dione; 4-(2-(benzyloxy)benzylidene)-1-phenylpyrazolidine-3,5-dione; (4Z)-4-[2-(benzyloxy)benzylidene]-1-phenylpyrazolidine-3,5-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1021453
TTD Drug ID
DMC0FLB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Proto-oncogene c-Src (SRC) DTT SRC 2.907 3.35 3.498 4.75
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Src (SRC) DTT SRC 6.45E-01 -0.08 -0.58
Proto-oncogene c-Src (SRC) DTT SRC 2.08E-03 -0.52 -1.62
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86.