Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMC13BQ)

• Drug Name: ICO-25 Drug Info
• Synonyms: Imuteran; Anti-MUC1 monoclonal antibodies, P Hertzen Moscow Cancer Research Institute; Anti-AG-4 antibodies, P Hertzen Moscow Cancer Research Institute

Indication

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMC13BQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mucin-1 (MUC1)	TTBHFYQ	MUC1_HUMAN	Not Available	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Mucin-1 (MUC1)	DTT	MUC1	3.485	8.525	9.106	5.714

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Breast cancer
• ICD Disease Classification: 2C60-2C65

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Mucin-1 (MUC1)	DTT	MUC1	4.59E-01	-0.07	-0.41

References

• [1] Atemonate and Imuteran: novel Russian monoclonal antibody-based therapeutic agents. Biotechnol J. 2007 Jul;2(7):863-70.
• [2] The role of epithelial antigens in diagnosis and staging of breast cancer. Arkh Patol. 2002 Nov-Dec;64(6):13-5.