Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMC7Y5F)

Drug Name
CAR-T cells recognizing EpCAM Drug Info
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1 [1]
Melanoma 2C30 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMC7Y5F

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor-associated calcium signal transducer 1 (EPCAM) TTZ8WH4 EPCAM_HUMAN CAR-T-Cell-Therapy [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 4.307 10.904 9.628 10.804
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 5.99E-02 -0.11 -1.11
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02915445) EpCAM CAR-T for Treatment of Nasopharyngeal Carcinoma and Breast Cancer