Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMC87DR)

Drug Name
GLPG-0259 Drug Info
Synonyms G-13919, GT-146, GT-1498, GT-1704, GT-314, GT-416, GT-514, GT-562
Indication
Disease Entry ICD 11 Status REF
Rheumatoid arthritis FA20 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
44462738
CAS Number
CAS 1195065-29-2
TTD Drug ID
DMC87DR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MAPK-activated protein kinase 5 (MAPKAPK5) TT3UJ7Z MAPK5_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
MAPK-activated protein kinase 5 (MAPKAPK5) DTT MAPKAPK5 3.982 5.603 5.823 6.501
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
MAPK-activated protein kinase 5 (MAPKAPK5) DTT MAPKAPK5 5.33E-03 0.87 1.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of Galapagos.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2096).