Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMC89HI)

Drug Name

NM-9308 Drug Info

Synonyms

Bikaciomab; Bikaciomab (AMD), NovelMed Therapeutics; Complement factor B inhibitor (age related maculardegeneration), NovelMed Therapeutics; Anti-factor B monoclonal antibody (age related macular degenration), NovelMed Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Age-related macular degeneration	9B75.0	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMC89HI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Complement factor B (CFB)	TTA0P7K	CFAB_HUMAN	Not Available	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Complement factor B (CFB)	DTT	CFB	10.419	4.895	7.235	6.78

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Age-related macular degeneration

ICD Disease Classification

9B75.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Complement factor B (CFB)	DTT	CFB	1.63E-02	0.07	0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339).