Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCGK6X)

Drug Name

PRO 140 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 5 (CCR5)	TT2CEJG	CCR5_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Human immunodeficiency virus-1 infection

ICD Disease Classification

1C62

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-C chemokine receptor type 5 (CCR5)	DTT	CCR5	9.30E-01	-0.08	-0.11

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT03902522) PRO 140 in Treatment-Experienced HIV-1 Subjects. U.S. National Institutes of Health.
2	The return of PRO 140, a CCR5-directed mAb. Curr Opin HIV AIDS. 2018 Jul;13(4):346-353.