Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCGVAB)

Drug Name

N/OFQ-(1-13)-NH2 Drug Info

Synonyms

RHMALYOXPBRJBG-CGUXNFSNSA-N; nociceptin(1-13)NH2; CHEMBL384755; 178064-02-3; OFQ/N; FGGFTGARKSARK; nociceptin(1-13)-NH2; Nociceptin (1-13)NH2; orphanin FQ(1-13)NH2; Demethyl-AMPA; nociceptin/orphanin FQ(1-13)NH2; Nociceptin Orphanin FQ1-13-NH2; H-FGGFTGARKSARK-NH2; AC1O44IO; GTPL1682; BDBM85822; N/OFQ(1-13)NH2; NC(1-13)NH2; Nociceptin analogueNC(1-13)-NH2; BDBM50106479; OFQ/N (1-11); AKOS024456547; NCGC00167157-01; nociceptin(1-13)NH2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6324645
TTD Drug ID: DMCGVAB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nociceptin receptor (OPRL1)	TTNT7K8	OPRX_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Nociceptin receptor (OPRL1)	DTT	OPRL1	4.86	4.72	4.162	4.692

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nociceptin receptor (OPRL1)	DTT	OPRL1	1.75E-01	0.05	0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1682).
2	Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide. J Med Chem. 1997 Jun 6;40(12):1789-93.