General Information of Drug (ID: DMCHILK)

Drug Name
1-(3,4-Dimethyl-phenyl)-2-phenyl-ethane-1,2-dione Drug Info
Synonyms
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione; 59411-15-3; PubChem22503; AC1M6ONN; Benzil-based compound, 19; AC1Q2DS8; SCHEMBL2156354; CHEMBL193140; 1-(3,4-Dimethyl-phenyl)-2-phenyl-ethane-1,2-dione; CTK5A9919; BDBM22741; DTXSID20368619; MolPort-000-513-246; ZINC3311689; AKOS000118620; MCULE-1712710570; NE45262; AJ-44881; ST010102; KB-213539; J3.541.808C; EN300-11497
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
2427416
CAS Number
CAS 59411-15-3
TTD Drug ID
DMCHILK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Liver carboxylesterase (CES1) DTT CES1 12.04 6.525 5.311 5.909
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Liver carboxylesterase (CES1) DTT CES1 3.82E-08 1.86 1.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15.