Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCIOSM)

Drug Name
CEP-18050 Drug Info
Synonyms ALK inhibitors (anaplastic large cell lymphoma); ALK inhibitors (anaplastic large cell lymphoma), Cephalon; Alk inhibitors (cancer), Cephalon
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Investigative [1]
Cross-matching ID
TTD Drug ID
DMCIOSM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ALK tyrosine kinase receptor (ALK) TTPMQSO ALK_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ALK tyrosine kinase receptor (ALK) DTT ALK 5.329 3.897 4.178 4.943
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Lymphoma
ICD Disease Classification 2A80-2A86
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ALK tyrosine kinase receptor (ALK) DTT ALK 7.19E-15 0.18 0.61
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839).