Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCRHVI)

Drug Name

1-[(prop-1-ylamino)ethyl]-1,1-bisphosphonic acid Drug Info

Synonyms

CHEMBL408745; [2-(Propylamino)ethane-1,1-Diyl]bis(Phosphonic Acid); SCHEMBL7074253; BDBM50374757; [2-(Propylamino)ethylidene]bisphosphonic acid; [1-phosphono-2-(propylamino)ethyl]phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15390273
TTD Drug ID: DMCRHVI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Geranyltranstransferase (FDPS)	TTIKWV4	FPPS_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Geranyltranstransferase (FDPS)	DTT	FDPS	7.06E-03	-0.73	-2.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90.