Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCTWIB)

Drug Name
AL102 Drug Info
Indication
Disease Entry ICD 11 Status REF
Desmoid tumour 2F7C Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMCTWIB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Gamma-secretase (GS) TT9W8GU APH1A_HUMAN; APH1B_HUMAN; PEN2_HUMAN; NICA_HUMAN; PSN1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Gamma-secretase (GS) DTT APH1A 7.23 7.775 7.538 7.928
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Desmoid tumour
ICD Disease Classification 2F7C
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Gamma-secretase (GS) DTT APH1A; APH1B; NCSTN; PSENEN; PSEN1 1.47E-02 -0.09 -0.37
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT04871282) A Study of AL102 in Patients With Progressing Desmoid Tumors (RINGSIDE). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Ayala Pharmaceuticals.