Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCV0BZ)

• Drug Name: RhTPO Drug Info
• Synonyms: TPIAO (TN)

Indication

Disease Entry	ICD 11	Status	REF
Idiopathic thrombocytopenic purpura	3B64.10	Discontinued in Phase 3	[1]

• Cross-matching ID: TTD Drug ID: DMCV0BZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thrombopoietin receptor (MPL)	TTIHYA4	TPOR_HUMAN	Agonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thrombopoietin receptor (MPL)	DTT	MPL	2.7	3.186	2.35	3.766

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Idiopathic thrombocytopenic purpura
• ICD Disease Classification: 3B64.10

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thrombopoietin receptor (MPL)	DTT	MPL	8.96E-01	0.07	0.28

References

• [1] Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54.