Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCWVPU)

Drug Name

CBP-501 Drug Info

Synonyms

UNII-XH2662798I; 565434-85-7; XH2662798I; Cdc25C phosphatase (211-221); CBP501; CBP 501; SCHEMBL17101340; Z-3278; D-Arginine, 4-benzoyl-D-phenylalanyl-D-seryl-D-tryptophyl-D-seryl-2,3,4,5,6-pentafluoro-D-phenylalanyl-3-cyclohexyl-D-alanyl-D-arginyl-D- arginyl-D-arginyl-D-glutaminyl-D-arginyl-

Indication

Disease Entry	ICD 11	Status	REF
Mesothelioma	2C51.2	Phase 1/2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

Cross-matching ID

PubChem CID: 16156006
CAS Number: CAS 565434-85-7
TTD Drug ID: DMCWVPU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MAPK-activated protein kinase 2 (MAPKAPK2)	TTMUG9D	MAPK2_HUMAN	Inhibitor	[3]
Microtubule affinity regulating kinase 3 (MARK3)	TT3DCYJ	MARK3_HUMAN	Inhibitor	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Microtubule affinity regulating kinase 3 (MARK3)	DTT	MARK3	6.252	6.067	6.071	6.236

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Mesothelioma

ICD Disease Classification

2C51.2

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Microtubule affinity regulating kinase 3 (MARK3)	DTT	MARK3	2.18E-06	0.13	0.48

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00700336) Study of CBP501 + Pemetrexed + Cisplatin on MPM (Phase I/II). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	National Cancer Institute Drug Dictionary (drug id 577812).