Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCWVS7)

Drug Name

CCX-025 Drug Info

Synonyms

CCX-807; CCR9 chemokine receptor-targeting therapeutic (gastrointestinal diseases), ChemoCentryx

Indication

Disease Entry	ICD 11	Status	REF
Crohn disease	DD70	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 9 (CCR9)	TTIPS8B	CCR9_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-C chemokine receptor type 9 (CCR9)	DTT	CCR9	5.109	5.146	5.603	6.888

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Crohn disease

ICD Disease Classification

DD70

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-C chemokine receptor type 9 (CCR9)	DTT	CCR9	7.74E-01	0.02	0.22

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of ChemoCentryx Inc.
2	Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29.