Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCY9PO)

Drug Name
Itarnafloxin Drug Info
Synonyms Quarfloxin; CX-3385; CX-3543; Quadruplex DNA oncogene inhibitor (cancer), Cylene; C-Myc/VEGF oncogene inhibitor (cancer), Cylene
Indication
Disease Entry ICD 11 Status REF
leukaemia 2A60-2B33 Phase 2 [1]
Cross-matching ID
PubChem CID
11635763
CAS Number
CAS 865311-47-3
TTD Drug ID
DMCY9PO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nucleolin (NCL) TTCSZH7 NUCL_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nucleolin (NCL) DTT NCL 9.151 9.31 9.237 8.858
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease leukaemia
ICD Disease Classification 2A60-2B33
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nucleolin (NCL) DTT NCL 3.15E-20 0.19 1.39
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Targeting G-quadruplexes in gene promoters: a novel anticancer strategy . Nat Rev Drug Discov. 2011 April; 10(4): 261-275.