Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD0GB4)

• Drug Name: PD-165167 Drug Info
• Synonyms: CHEMBL332154; SCHEMBL8169927; BDBM50080797; 7-[[(2-Anilinoethyl)amino]methyl]coumarin; L017812

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 9926143
  TTD Drug ID: DMD0GB4

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Antagonist	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D4 receptor (D4R)	DTT	DRD4	2.138	1.766	1.322	1

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Schizophrenia
• ICD Disease Classification: 6A20

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D4 receptor (D4R)	DTT	DRD4	1.90E-01	0.19	0.76

References

• [1] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.