Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD16JK)

Drug Name
RG-7816 Drug Info
Indication
Disease Entry ICD 11 Status REF
Autism spectrum disorder 6A02 Phase 1 [1]
Cross-matching ID
PubChem CID
134588268
TTD Drug ID
DMD16JK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-5 (GABRA5) TTNZPQ1 GBRA5_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
GABA(A) receptor alpha-5 (GABRA5) DTT GABRA5 4.883 0.926 1.536 4.365
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Autism spectrum disorder
ICD Disease Classification 6A02
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
GABA(A) receptor alpha-5 (GABRA5) DTT GABRA5 3.15E-09 -0.68 -0.61
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.