Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD1QOH)

Drug Name

GNF-PF-2812 Drug Info

Synonyms

3-(4-Methoxyphenyl)-5H-indeno[1,2-c]pyridazin-5-one; GNF-PF-2812; NSC663884; CHEMBL125044; 147508-58-5; 3-(4-methoxyphenyl)indeno[1,2-c]pyridazin-5-one; 5H-indeno[1,2-c]pyridazin-5-one, 3-(4-methoxyphenyl)-; AC1Q6KMT; AC1L8E6Y; Oprea1_523550; CBDivE_007579; MLS000691948; cid_379338; CTK7A3357; BDBM21618; KS-00001QSJ; MolPort-002-851-046; HMS2631I03; ZINC196663; STK336082; MMV666026; Indeno[1,2-c]pyridazin-5-one, 6; AKOS005075095; MCULE-6151549558; NSC-663884; SMR000333991; NCI60_021917

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 379338
TTD Drug ID: DMD1QOH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin II receptor type-1 (AGTR1)	TT8DBY3	AGTR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Angiotensin II receptor type-1 (AGTR1)	DTT	AGTR1	9.315	6.241	6.761	5.625

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Angiotensin II receptor type-1 (AGTR1)	DTT	AGTR1	8.95E-01	1.34E-02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.