Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD1V7I)

Drug Name

Celgosivir Drug Info

Synonyms

BuCast; MDL 28574; B-CAST; MBI-3253; MDL 28,574; MDL 28,574A; MDL-28574; MX-3253; VIR-222; Butanoic acid, (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester; [(1S,6S,7S,8R,8aR)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate; (1S,6S,7S,8R,8aR)-Octahydro-1,7,8-trihydroxy-6-indolizinyl butyrate;6-O-Butanoylcastanospermine

Indication

Disease Entry	ICD 11	Status	REF
Dengue fever	1D2Z	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 60734
CAS Number: CAS 121104-96-9
TTD Drug ID: DMD1V7I

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Intestinal maltase-glucoamylase (MGAM)	TTXWASR	MGA_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Dengue fever

ICD Disease Classification

1D2Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Intestinal maltase-glucoamylase (MGAM)	DTT	MGAM	4.59E-01	-0.02	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003977)
2	Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.Curr Opin Investig Drugs.2009 Aug;10(8):860-70.