Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD3CUJ)

• Drug Name: T-5224 Drug Info
• Synonyms: AKOS003047196; T5224

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 23626877
  TTD Drug ID: DMD3CUJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transcription factor AP-1 (JUN)	TTN3GBV	JUN_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Transcription factor AP-1 (JUN)	DTT	JUN	7.311	6.659	6.272	7.023

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 15 Disease of the musculoskeletal system/connective tissue
• Disease Class: ICD-11: FA20 Rheumatoid arthritis
• The Studied Tissue: Synovial tissue
• The Studied Disease: Rheumatoid arthritis [ICD-11:FA20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Transcription factor AP-1 (JUN)	DTT	JUN	1.13E-03	0.92	1.87

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016746)
• [2] CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.