Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD51RN)

Drug Name
TAK-448 Drug Info
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 2 [1]
Cross-matching ID
PubChem CID
46700761
CAS Number
CAS 1234319-68-6
TTD Drug ID
DMD51RN

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metastasis-suppressor KiSS-1 (KISS1) TTU2O6T KISS1_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Metastasis-suppressor KiSS-1 (KISS1) DTT KISS1 2.632 2.293 1.963 3.524
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Prostate
The Studied Disease Prostate cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Metastasis-suppressor KiSS-1 (KISS1) DTT KISS1 6.40E-01 -0.01 -0.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02381288) Effects of TAK-448 in Middle-aged and Older Men With Low Testosterone. U.S. National Institutes of Health.
2 Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.Eur J Pharmacol.2014 Jul 15;735:77-85.