Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD6CLG)

Drug Name

TZP-201 Drug Info

Synonyms

JTZ-2002; IBS-D therapeutic, Tranzyme; Irritable bowel syndrome (diarrhea type) therapeutic, Tranzyme; Motilin antagonists (IBS/ fuctional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/ functional dyspepsia), Tranzyme; Motilin receptor antagonists (irritable bowel syndrome/diarrhea), Tranzyme

Indication

Disease Entry	ICD 11	Status	REF
Diarrhea	ME05.1	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMD6CLG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Motilin receptor (MLNR)	TT953CX	MTLR_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Motilin receptor (MLNR)	DTT	MLNR	1.807	2	3.17	5.087

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diarrhea

ICD Disease Classification

ME05.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Motilin receptor (MLNR)	DTT	MLNR	6.35E-02	-0.06	-0.27

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297).