Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDK59X)

Drug Name

(1,1-Difluoro-pentadecyl)-phosphonic acid Drug Info

Synonyms

CHEMBL188859; (1,1-Difluoro-pentadecyl)-phosphonic acid; SCHEMBL193245; YGXPAGSHLFJKFV-UHFFFAOYSA-N; BDBM50170861; ZINC36178965; (1,1-Difluoro-pentadecyl)Phosphonic Acid; (1,1-Difluoro-pentadecyl) Phosphonic Acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11393306
TTD Drug ID: DMDK59X

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysophosphatidic acid receptor 1 (LPAR1)	TTQ6S1K	LPAR1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Lysophosphatidic acid receptor 1 (LPAR1)	DTT	LPAR1	5.998	6.919	6.589	6.975

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Lysophosphatidic acid receptor 1 (LPAR1)	DTT	LPAR1	6.48E-01	-0.04	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30.