Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDSCQG)

Drug Name
PF-04840082 Drug Info
Indication
Disease Entry ICD 11 Status REF
Osteoporosis FB83.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMDSCQG

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dickkopf-related protein 1 (DKK1) TTE3RAC DKK1_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dickkopf-related protein 1 (DKK1) DTT DKK1 5.591 4.916 5.174 4.848
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Osteoporosis
ICD Disease Classification FB83.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dickkopf-related protein 1 (DKK1) DTT DKK1 5.31E-07 2.97 5.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01293487) Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.. U.S. National Institutes of Health.
2 The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010 Apr;333(1):2-13.