Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDUIG3)

Drug Name
ISIS 11221 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMDUIG3

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bcl-x messenger RNA (BCL2L1 mRNA) TTRE6AX B2CL1_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Bcl-x messenger RNA (BCL2L1 mRNA) DTT BCL2L1 4.863 5.664 6.092 5.843
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Bcl-x messenger RNA (BCL2L1 mRNA) DTT BCL2L1 7.28E-13 -0.55 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 US patent application no. 7,148,204, Antisense modulation of bcl-x expression.