Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDUKMR)

Drug Name
CAT4001 Drug Info
Indication
Disease Entry ICD 11 Status REF
Alpha-1 antitrypsin deficiency 5C5A Preclinical [1]
Friedreich's ataxia 8A03.10 Preclinical [1]
Cross-matching ID
TTD Drug ID
DMDUKMR

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Nuclear factor erythroid 2-related factor 2 (Nrf2) TTA6ZN2 NF2L2_HUMAN Activator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nuclear factor erythroid 2-related factor 2 (Nrf2) DTT NFE2L2 8.964 8.362 9.046 8.808
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alpha-1 antitrypsin deficiency
ICD Disease Classification 5C5A
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nuclear factor erythroid 2-related factor 2 (Nrf2) DTT NFE2L2 4.75E-12 -0.28 -0.58
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317.